Bayer Sees Significant, But Smaller, Asundexian Opportunity

BMS Still Confident In Competing Asset Milvexian

Scrip spoke with Bayer’s head of pharma R&D Christian Rommel at the J.P. Morgan Healthcare Conference about the road ahead for Factor XIa inhibitor asundexian after its atrial fibrillation setback.

Heart activity on monitor in intensive care unit — Bayer sees significant opportunity for asundexian in stroke despite AF miss • Source: Shutterstock

At the J.P. Morgan Healthcare Conference in 2023, Bayer AG forecast that four commercial and late-stage products would generate peak revenues totaling €12bn, including €5bn alone from Factor XIa inhibitor asundexian for atrial fibrillation (AF) and stroke and €1bn for neurokinin-1,3 (NK-1,3) receptor antagonist elinzanetant for vasomotor symptoms in women going through menopause. A year later, the company has positive Phase III results for elinzanetant, but after suffering a setback for asundexian.

Bayer reported positive results for two Phase III clinical trials of elinzanetant on opening day of J.P. Morgan 2024 in...