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Encouraging Phase III Data For Blenrep But GSK Remains Cautious On Market Return

 
• By Andrew McConaghie

Data may prove too little too late for the antibody drug conjugate, as GSK takes a cautious stance over future commercial viability.

New GSK House
• Source: GSK

Newly unveiled Phase III data could help GSK bring its multiple myeloma therapy Blenrep back to the market but it will await a further positive readout before making a decision.

GSK’s antibody drug conjugate Blenrep (belantamab mafodotin) was removed from the US market in late 2022 when it failed to show improved progression free survival (PFS) as a fifth-line monotherapy for patients with relapsed or

Key Takeaways

  • Blenrep was withdrawn in the US in late 2021, but could return if new combination data is strong enough

  • That may hinge on overall survival data (not yet mature) from the DREAMM-7 study, and DREAMM-8, expected later this year

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