Amgen, Inc. has taken a divergent path with its obesity drug candidate maridebart cafraglutide (MariTide, AMG 133), a GLP-1 agonist and GIP receptor (GIPR) antagonist, which has delivered intriguing weight loss in a Phase I clinical trial despite differing from Eli Lilly and Company’s Zepbound (tirzepatide), which agonizes both GLP-1 and GIP. Phase II data for MariTide are not expected until late 2024, leaving observers impatient for data clarifying Amgen’s approach.
Key Takeaways
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Amgen’s Q4 earnings call was dominated by questions about the company’s maridebart cafraglutide (MariTide, AMG 133), a GLP-1 agonist and GIP receptor (GIPR) antagonist.
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Recently published detailed Phase I results raised additional concerns about the obesity candidate for which the company will report Phase II data in late 2024
While Amgen announced a 20% increase in Q4 revenue to $8.2bn, thanks to the closing of its $27.8bn acquisition of Horizon Therapeutics plc early in the quarter and gains for several of its products, the Q&A portion of the company’s 6 February sales and earnings call was dominated by questions about MariTide
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