Amgen Testing Whether Different Is Better In Obesity, With Data Due This Year

GIP Receptor Antagonism Versus Agonism On Trial

Amgen’s obesity drug MariTide will not have Phase II results until late 2024, but the company’s Q4 earnings call was dominated by questions seeking insight about the drug’s potential.

Weight scale instrument for measurement balance of people body concept
Amgen's Phase II MariTide data are expected in late 2024 • Source: Shutterstock

Amgen, Inc. has taken a divergent path with its obesity drug candidate maridebart cafraglutide (MariTide, AMG 133), a GLP-1 agonist and GIP receptor (GIPR) antagonist, which has delivered intriguing weight loss in a Phase I clinical trial despite differing from Eli Lilly and Company’s Zepbound (tirzepatide), which agonizes both GLP-1 and GIP. Phase II data for MariTide are not expected until late 2024, leaving observers impatient for data clarifying Amgen’s approach.

Key Takeaways
  • Amgen’s Q4 earnings call was dominated by questions about the company’s maridebart cafraglutide (MariTide, AMG 133), a GLP-1 agonist and GIP receptor (GIPR) antagonist.

  • Recently published detailed Phase I results raised additional concerns about the obesity candidate for which the company will report Phase II data in late 2024

While Amgen announced a 20% increase in Q4 revenue to $8.2bn, thanks to the closing of its $27.8bn acquisition of Horizon Therapeutics plc early in the quarter and gains for several of its products, the Q&A portion of the company’s 6 February sales and earnings call was dominated by questions about MariTide

Read the full article – start your free trial today!

Join thousands of industry professionals who rely on Scrip for daily insights

  • Start your 7-day free trial
  • Explore trusted news, analysis, and insights
  • Access comprehensive global coverage
  • Enjoy instant access – no credit card required

More from Clinical Trials

Pipeline Watch: Six Approvals And Thirteen Phase III Readouts

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.

Viatris Will File ‘Fast-Acting’ Meloxicam For FDA Approval This Year

 
• By 

Seven years after acquiring it, Viatris will seek approval of a meloxicam formulation for acute pain backed by data from two Phase III studies in post-surgical pain settings.

CRISPR Therapeutics Unveils Promising Early In Vivo Cholesterol-Lowering Results

 

The Phase I results are the best to date among ANGPTL3-targeting candidates in the pipeline, but analysts will wait for further updates before predicting a likely winner.

Sanofi R&D Head’s Words Of Wisdom For Biotechs

 
• By 

Houman Ashrafian tells delegates at Swiss Biotech Day that ‘literally only two things matter in our industry – target credentialing and differentiated pharmacology. The rest is execution.’

More from R&D

Sanofi R&D Head’s Words Of Wisdom For Biotechs

 
• By 

Houman Ashrafian tells delegates at Swiss Biotech Day that ‘literally only two things matter in our industry – target credentialing and differentiated pharmacology. The rest is execution.’

Marea Eyes Cardioprotective Benefit With ANGPTL4 Inhibition

 
• By 

Phase IIa data for ANGPTL4-targeted antibody shows reduced triglycerides and remnant cholesterol, which Marea asserts indicates potential to protect against cardiovascular outcomes.

First Win For AstraZeneca’s Enhertu In Early-Stage Breast Cancer Treatment

 

Already dominating in later lines of breast cancer treatment, Enhertu could now displace both chemotherapy combinations and Roche’s Kadcyla in early-stage HER2-positive patients.