As the industry awaits the potential first approval of a metabolic-associated steatohepatitis (MASH) drug on 14 March, Ionis Pharmaceuticals, Inc. may have worked its way into the race to follow Madrigal Pharmaceuticals, Inc.’s THRβ agonist resmetirom into the market, unveiling top-line Phase II data on 13 March for its antisense DGAT2 inhibitor ION224 that met statistical significance for biopsy-demonstrated improvement in disease score along with a secondary endpoint of MASH resolution.
Ionis Could Be A Factor In MASH With Positive Phase II Data
Ionis’s DGAT2 inhibitor showed potential to improve disease activity score and resolve metabolic-associated steatohepatitis in a Phase II study, but analysts point to fibrosis-reduction data as competitively intriguing.
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