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Oculis Looks To Move Dry Eye Candidate To Phase III Despite Mixed Dataset

 
• By Joseph Haas

Oculis’s licaminlimab showed ability to treat a sign of dry eye disease in a genetic subpopulation, but data in the fuller Phase IIb trial enrollment were less impressive.

Dry eye disease
Oculis thinks its candidate can benefit a genetic subset of dry eye patients • Source: Shutterstock

Oculis S.A. missed statistical significance in most signs of dry eye disease in the 122-patient RELIEF study of licaminlimab (OCS-2), but the trial did reach statistical significance in a biomarker-identified subgroup on one sign of the disease, corneal inflammation, and the company believes that the positive trends overall support moving into Phase III.

Key Takeaways

  • Oculis is planning to target inflammation and apoptosis in dry eye disease with its novel anti-TNFα eye drop licaminlimab.

  • The Swiss biotech would like...

During a same-day call, Oculis CEO Riad Sherif talked about convening an end-of-Phase II meeting with the US Food and Drug Administration to design a Phase III program for licaminlimab...

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