Eisai Regains Full Control Of ADC Program After Bristol R&D Reprioritization

The Japanese pharma said it plans to accelerate development of the antibody-drug conjugate farletuzumab ecteribulin for solid tumors and will develop it independently.

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Eisai and Bristol ended an ADC collaboration • Source: Shutterstock

Eisai Co., Ltd.’s partnership with Bristol Myers Squibb Company on the antibody-drug conjugate farletuzumab ecteribulin (FZEC) appears to be a casualty of Bristol’s R&D prioritization program. Eisai announced the end of the three-year partnership on FZEC, formerly known as MORAb-202, on 1 July and said it plans to accelerate development of the product and conduct development and commercialization independently.

Key Takeaways
  • Eisai plans to accelerate development of farletuzumab ecteribulin after regaining full rights from Bristol Myers Squibb.
  • Farletuzumab ecteribulin is a folate receptor alpha (FRα)-targeting ADC in development for ovarian and other cancers, but is behind rivals, including AbbVie’s marketed Elahere

Bristol paid handsomely for rights to co-develop and co-commercialize FZEC in regions including the US, Europe and Asia in 2021. (Also see "BMS, Eisai Team Up To Accelerate Development Of Solid-Tumor ADC" - Scrip, 18 June, 2021

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