Currently just one class of drugs is recommended for the treatment of patients with heart failure with mildly reduced or preserved ejection fraction: the SGLT2 inhibitors, namely Jardiance and Farxiga. Data presented at the annual congress of the European Society of Cardiology in London on 1 September could change that.
ESC: Kerendia Hits In Heart Failure, But Usage Unclear
Bayer’s mineralocorticoid receptor antagonist is effective in heart failure with mildly reduced or preserved ejection fraction – but should it be used instead of SGLT2s, or on top of them?

More from Clinical Trials
The firm has lofty ambitions for the aldosterone synthase inhibitor to treat hypertension and kidney disease.
The ZENITH study is a landmark for Merck’s first-in-class activin signalling inhibitor and pulmonary arterial hypertension treatment.
Seeking cell therapy approaches to cure type 1 diabetes, Vertex abandons a candidate encapsulated to avoid immune system detection but hopes to file another candidate for approval in 2026.
A Phase III trial testing the cortisol modulator showed a benefit on PFS and OS in patients with platinum-resistant ovarian cancer.
More from R&D
The UK giant is forecasting peak sales of $5bn plus
Novo’s semaglutide has shown its benefits as an injectable in patients with peripheral arterial disease and as an oral agent in cardiovascular outcomes, but stronger results are expected soon from Lilly’s tirzepatide.
Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.