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Another Miss For LAG-3 In MSS Colorectal Cancer In Keytruda Combo Study

 
• By Kevin Grogan

Nine months after Bristol Myers Squibb’s LAG-3/PD-L1 combination Opdualag failed a Phase III trial in microsatellite stable metastatic colorectal cancer, Merck & Co's fixed-dose combo of favezelimab and Keytruda has suffered the same fate in the indication.

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The theory that LAG-3 inhibitors could help improve survival for colorectal cancer patients has suffered another setback with the failure of a late-stage trial evaluating Merck & Co., Inc.'s favezelimab in combination with the US giant's PD-1 inhibitor Keytruda.

Merck has announced that the Phase III KEYFORM-007 trial evaluating the fixed-dose combination of the anti-LAG3 antibody favezelimab and Keytruda (pembrolizumab) did not meet its primary endpoint of overall survival (OS) for the treatment of patients with previously treated PD-L1 positive microsatellite stable (MSS) metastatic colorectal cancer

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Pipeline Watch: Thirteen Approvals And Ten Phase III Readouts

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.