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Another Miss For LAG-3 In MSS Colorectal Cancer In Keytruda Combo Study

 
• By Kevin Grogan

Nine months after Bristol Myers Squibb’s LAG-3/PD-L1 combination Opdualag failed a Phase III trial in microsatellite stable metastatic colorectal cancer, Merck & Co's fixed-dose combo of favezelimab and Keytruda has suffered the same fate in the indication.

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• Source: Shutterstock

The theory that LAG-3 inhibitors could help improve survival for colorectal cancer patients has suffered another setback with the failure of a late-stage trial evaluating Merck & Co., Inc.'s favezelimab in combination with the US giant's PD-1 inhibitor Keytruda.

Merck has announced that the Phase III KEYFORM-007 trial evaluating the fixed-dose combination of the anti-LAG3 antibody favezelimab and Keytruda...

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• By Jessica Merrill

Gefurulimab will give AstraZeneca a new option to compete against Argenx’s Vyvgart Hytrulo, which is available subcutaneously.

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Obesity Beyond GLP-1s: Amylins – The Next Frontier

 
• By Aakash Babu

In this series of articles, we look at different mechanisms of actions beyond GLP-1s that could determine the obesity drug landscape in the coming years. First on our list – amylin receptor agonists, which analysts expect to grow into a $50bn market opportunity.