Enanta’s Phase II Challenge Data Position A Second Potential RSV Therapy

One of Enanta’s two antivirals in development for RSV showed efficacy in a healthy patient challenge trial. But analysts say field studies of infected patients are more telling.

RSV illus
Enanta is advancing two antivirals to treat RSV infections • Source: Shutterstock

Virology-focused Enanta Pharmaceuticals, Inc. took a positive step in its two-mechanism approach to providing a treatment for respiratory syncytial virus (RSV) on 26 September as its RSV L-protein inhibitor EDP-323 succeeded in a Phase IIa challenge study of healthy volunteers. But analysts called upcoming Phase IIb data for the firm’s N-protein inhibitor zelicapavir in pediatric RSV patients potentially the greater inflection point for Enanta’s program.

Key Takeaways
  • Enanta, with two antivirals in mid-stage development to treat RSV infection, reported positive Phase IIa challenge data for its novel RSV L-protein inhibitor.

  • The...

On a same-day call, Enanta CEO Jay Luly asserted that the two Phase II candidates comprise “the leading portfolio of RSV treatments in development today.” While vaccines to prevent RSV...

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