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Intellia Moves Into Phase III With NTLA-2002, But Concerns Remain

 
• By Alaric DeArment

The gene-editing therapy produced functional cures in eight of 11 patients receiving the go-forward 50mg dose, but the rate fell short of what some investors had hoped for.

angioedema word cube with background
• Source: Shutterstock

Intellia Therapeutics, Inc.’s NTLA-2002 holds a strong position as it heads into Phase III development for hereditary angioedema (HAE), with Phase II data showing a high rate of functional cure. However, three patients continued to experience what could be HAE attacks.

On 24 October, the Cambridge, MA-based CRISPR-focused biotech published data from the Phase II portion of its Phase I/II study...

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