Stoke Gets Runway, Biogen A Late-Stage Asset In Epilepsy Collaboration

Biogen will pay $165m up front for ex-North American rights to Stoke’s Phase III-ready Dravet syndrome candidate, an antisense drug offering disease-modifying potential.

Epilepsy
Stoke is partnering with Biogen on its antisense candidate for a rare type of epilepsy

In what observers are calling a sensible deal for both sides, Stoke Therapeutics and Biogen revealed on 18 February that they will collaborate on development and commercialization of Stoke’s antisense oligonucleotide (ASO) therapy for Dravet syndrome, zorevunersen (STK-001). The deal brings Stoke added financial runway and an experienced commercial partner that has succeeded with ASO therapies, while Biogen obtains a late-stage candidate that may offer blockbuster sales in an underserved rare disease.

Key Takeaways
  • Stoke is partnering its Phase III-ready Dravet syndrome candidate with Biogen in a deal that brings Stoke increased financial runway and an ideal commercial partner...

Cambridge, MA-based Stoke reported encouraging Phase I/IIa data for zorevunersen last March indicating that its drug demonstrated an ability to address the underlying cause of Dravet,...

Read the full article – start your free trial today!

Join thousands of industry professionals who rely on Scrip for daily insights

  • Start your 7-day free trial
  • Explore trusted news, analysis, and insights
  • Access comprehensive global coverage
  • Enjoy instant access – no credit card required

More from Advanced Therapies

More from Therapy Areas

ASCO: J&J Banks On T-Cell Engager’s Safety In Prostate Cancer

 

The company highlighted the KLK2-targeting agent’s safety at ASCO but it may have to rely on combinations to make pasritamig competitive.

ASCO: Regeneron Looks To Become Bigger Immuno-Oncology Player

 

The drugmaker presented oral abstracts at the meeting for Libtayo in adjuvant cutaneous squamous-cell carcinoma and linvoseltamab in multiple myeloma.

ASCO: Lupin Presents Early Data On PRMT5 Inhibitor

 
• By 

ASCO sees the debut of Lupin’s PRMT5 inhibitor candidate LRNP7457, currently in Phase I studies in India. While no drug with this mechanism of action has been approved anywhere so far, several candidates are in clinical trials.