Five Companies Heading Toward 2030 With Wind At Their Back

Which Big Companies Face The Least LOE Hit?

Novo, Sanofi, Gilead, Lilly and Bayer are among the big pharmas with the fewest expected US exclusivity losses from 2026-2030.

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Key Takeaways
  • When it comes to the industry-wide patent cliff coming in the back half of the decade, a lucky few are well positioned to weather the storm.
  • A Scrip analysis of Evaluate Pharma data shows the drug makers that are positioned lose 15% or less of 2025 forecast US revenues from drugs going off patent from 2026-2030.
  • Novo Nordisk, Sanofi, Gilead, Eli Lilly and Bayer are five of the top drug manufacturers well positioned from an LOE perspective.

The biopharmaceutical industry is heading into a tumultuous period from 2026-2030, which will be marked by the loss of exclusivity (LOE) in the US of some of the industry’s biggest-selling brands

When it comes to the industry-wide patent cliff coming in the back half of the decade, a lucky few are even

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