J&J Dreams Of ICONIC Status For Icotrokinra

Having bested BMS's oral psoriasis drug Sotyktu, the closely watched once-daily IL-23 blocker is going head-to-head with J&J's own autoimmune mega-blockbuster Stelara.

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J&J and analysts trumpet the efficacy and safety shown by icotrokinra • Source: Shutterstock

More positive data on icotrokinra have lent support to Johnson & Johnson’s claim that its first-in-class oral therapy has to potential to set a new standard of treatment in plaque psoriasis.

Key Takeaways
  • Data presented at the AAD meeting showed that nearly half of patients treated with icotrokinra achieved completely clear skin
  • The once-daily oral peptide that blocks the interleukin-23 receptor is showing efficacy that is not miles off the injectables and excellent tolerability

At a busy American Academy of Dermatology meeting in Orlando for the healthcare giant, J&J presented more data from the Phase III ICONIC-LEAD trial of icotrokinra. These followed the topline results published in November which showed that at week 16, 64.7% of patients taking the once-daily oral peptide that blocks the interleukin-23 receptor achieved clear or almost clear skin measured using the Investigator’s Global Assessment (IGA) scale, ie, a score of 0 or 1, while 49

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