Novo Nordisk reported a successful Phase IIIb result for high-dose semaglutide in obese adults on 17 January, but analysts pointed out that while the data topped the weight loss demonstrated by the drug’s marketed 2.4mg dose of Wegovy, it fell short of the efficacy produced by Lilly’s Zepbound (tirzepatide) at the same time point in a Phase III study.
High-Dose Semaglutide Data A Mixed Bag For Novo Nordisk
Semaglutide 7.2mg bests placebo for weight loss at 72 weeks, but with efficacy lower than seen with Novo Nordisk’s CagriSema or Lilly’s Zepbound.

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