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In Brief: PolyPid’s D-PLEX100 Aces Phase III Trial, US Partner, Submission Eyed

Second Time Lucky

 
• By Sushmita Panda

PolyPid's D-PLEX100 meets Phase III endpoints this time around, significantly reducing surgical point infections in abdominal colorectal surgery, and is set for a US approval submission early next year.

PolyPid seeking US partner for lead candidate D-PLEX100 for post-surgery infections.  • Source: Shutterstock

Following a missed Phase III endpoint in 2022, PolyPid has reported positive top-line results from its Phase III SHIELD II trial with D-PLEX100 for the prevention of surgical site infections (SSIs) in patients undergoing major abdominal colorectal surgery.

The doxycycline-containing, sustained release polymer matrix product, the Israeli firm’s lead candidate, has US Fast Track designation and is on...

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