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Roche’s Brain Shuttle Delivers In Alzheimer’s, Moves Ahead To Phase III

 
• By Andrew McConaghie

By allowing it to enter the brain more easily, trontinemab’s brain shuttle brings more patients to ‘amyloid zero’ levels faster, and with fewer brain swelling side effects.

PET CT scan of Human Brain (Axial view Positron Emission Tomography)
PET scans, MRI monitoring and infusions complicate treatment with anti-amyloid antibodies • Source: Shutterstock

Roche has unveiled promising Phase Ib/IIa trial results suggesting its “brain shuttle” Alzheimer’s disease candidate trontinemab could be safer and more effective than approved therapies, and will begin a Phase III study later this year.

Roche needed to be convinced that trontinemab could do better than the disappointing profiles of approved beta-amyloid targeting antibodies, Biogen/Eisai’s

Key Takeaways
  • 81% of participants reached 'amyloid negative' status after 28 weeks - further and faster than seen in longer rival Phase III studies

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