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UCB Weighs Up Alzheimer’s Drug Future After Phase II Miss And Roche Exit

The Phase II results suggest subgroups of patients could possibly benefit from bepranemab, but with Roche’s exit, the odds are stacked against the anti-tau candidate.

UCB
• Source: UCB

UCB is still considering what to do with its anti-tau candidate for Alzheimer’s disease, bepranemab, after Roche’s decision to quit their partnership and a Phase II trial failure.

While its TOGETHER trial of bepranemab in people with prodromal-to-mild Alzheimer’s disease was selected for a late-breaking symposium to close the Clinical Trials on Alzheimer’s Disease (CTAD) conference,

Key Takeaways
  • Bepranemab is one of a new generation of antibodies targeting the mid-region of tau, aimed at achieving greater potency than the many older failed drugs in the category

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