Wave Wants To Put The Joy Back Into Weight-Loss Drugs

The company believes its WVE-007 can improve on GLP-1 agonists by preserving muscle mass while also not interfering with the pleasure of eating. Promising mouse data are still to be confirmed in humans, however.

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Wave Life Sciences is developing a new weight loss candidate, WVE-007, which it believes could not only avoid muscle-loss problems but also the loss of pleasure in eating that some patients report when taking GLP-1 agonists.

Known medically as anhedonia, the adverse event is not listed in the official prescribing information for Novo Nordisk’s semaglutide products and Eli Lilly’s tirzepatide brands, but has become widely reported on social

Key Takeaways
  • Wave has promising data from its Duchenne muscular dystrophy and AATD rare disease candidates, but a successful obesity drug would transform the company's fortunes

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