Astellas Gets CLDN.18.2-Targeted ADC From China’s Evopoint

Astellas will pay $130m up front for near-global rights to a Phase I/II antibody-drug conjugate that will add to its portfolio of CLDN.18.2-targeted drugs, including Vyloy.

ADC
Astellas licenses Evopoint's CLDN18.2-targeted ADC • Source: Shutterstock

Following up on last year’s approval of Vyloy (zolbetuximab) and looking to build its pipeline of antibody-drug conjugate (ADC) therapies for cancer, Astellas unveiled a licensing agreement with China’s Evopoint Biosciences on 29 May. In exchange for $130m up front and earnouts that could push the deal value well above $1bn, Astellas will obtain ex-China rights to Phase I/II CLDN.18.2-targeted XNW27011.

Key Takeaways
  • Astellas will pay Evopoint $130m up front and up to $1.34bn in total for ex-China rights to a Phase I/II CLDN.18.2-targeted ADC.

Vyloy is the first US Food and Drug Administration-approved drug that targets CLDN.18.2. It was approved...

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