Amgen’s MariTide Data Not The Hit Investors Sought

MariTide demonstrated solid 52-week weight loss in a Phase II update, but high rates of vomiting. Amgen is adjusting dosing in Phase III to seek a better tolerability profile.

Close up of Amgen sign at its headquarters in Thousand Oaks, California, USA
Overall profile for Amgen's MariTide in obesity gets mixed reviews • Source: Shutterstock

Amgen’s updated Phase II data for MariTide in obesity may not have been the results the firm was looking for, but Amgen is trying to assure investors that based on learnings from an ongoing Phase II trial and a Phase I pharmacokinetic study, it knows the right approach in Phase III to improve the bispecific GLP-1 agonist/GIP receptor antagonist antibody’s gastrointestinal tolerability without sacrificing efficacy.

Key Takeaways
  • Amgen updated the field on its Phase II bispecific antibody for obesity, showing 52-week data that analysts called competitive but with troubling tolerability findings.

The just-concluded American Diabetes Association annual meeting provided a platform for several obesity updates. Eli Lilly won the biggest plaudits...

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