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Marea Eyes Cardioprotective Benefit With ANGPTL4 Inhibition

 
• By Joseph Haas

Phase IIa data for ANGPTL4-targeted antibody shows reduced triglycerides and remnant cholesterol, which Marea asserts indicates potential to protect against cardiovascular outcomes.

cardiovascular system
Marea hopes ANGPTL4 inhibition can benefit high-risk cardiovascular patients • Source: Shutterstock

Unveiled in 2024 with $190m in combined series A and B financing, Marea Therapeutics is aiming high by seeking to eventually demonstrate a cardioprotective benefit for MAR001, its Phase II ANGPTL4-targeted antibody. The South San Francisco firm reported positive Phase IIa data for three doses of MAR001 at the European Atherosclerosis Society Congress in Scotland on 7 May and plans to initiate a Phase IIb trial later this year.

Key Takeaways
  • 2024 start-up Marea presented Phase IIa data showing that its ANGPTL4-targeted antibody can reduce triglycerides and remnant cholesterol.

In an interview, Marea CEO Josh Lehrer said that although there might be quicker and less resource-expensive ways to bring...

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