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J&J’s Trispecific Antibody For Myeloma Offers Improved Safety, Potency Over Bispecifics

 
• By Alaric DeArment

The drugmaker presented data from its Phase I study of JNJ-79635322 at ASCO and EHA showing a 100% response rate in BCMA- and GPRC5D-naïve patients.

(Alaric DeArment)

Johnson & Johnson has sought to carve out a leading position in the treatment of multiple myeloma, and presentations at the American Society of Clinical Oncology and European Hematology Association meetings showcased promising early data for JNJ-79635322 (JNJ-5322), a trispecific monoclonal antibody that goes after two key antigen targets in the disease.

Key Takeaways
  • J&J presented early data for its trispecific antibody targeting BCMA and GPRC5D in myeloma, with all patients who had not received prior treatments targeting those antigens responding.

The drug maker presented Phase I overall response rate (ORR) data for the BCMAxGPRC5DxCD3-targeting antibody in an oral session at...

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