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AstraZeneca And Daiichi’s Dato-DXd Set For More Modest Market Entry Than First Hoped

 
• By Andrew McConaghie

After setbacks and a withdrawn filing, Dato-DXd is back on track for a potential second-line approval later this year in EGFR-mutant lung cancer. The partners are still counting on success in first line lung cancer and breast cancer treatment

Daria Artemenko/Alamy Stock Photo
(Daria Artemenko / Alamy Stock Ph/Alamy Stock Photo)

AstraZeneca and Daiichi Sankyo look likely to gain a first approval for their antibody-drug conjugate, datopotamab deruxtecan (Dato-DXd), later this year, but for a much smaller patient group than originally desired.

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• By Andrew McConaghie

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• By Kevin Grogan

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Novartis $23bn US Investment Is Music To Trump’s Ears

 
• By Kevin Grogan

The Swiss major follows Lilly and J&J in committing to a significant spend on US manufacturing.

Biotech Leaders Fear FDA Disruption Is Causing Delays

 
• By Jessica Merrill

A letter to US Senate HELP Committee Chair Bill Cassiday sounds an alarm about irreparable damage to the FDA, signed by more than 200 biotech executives and investors.

Pipeline Growth Slowed In 2024 But Oncology And Neurologicals Held Strong

 
• By Alexandra Shimmings

There was a reduction in the rate of expansion of the pharma pipeline last year but 2024 also saw another welcome increase in the number of drug candidates in Phase III following years of stagnation.