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In Two Recent Trials, Devices Trump Rx

Results of two recent studies reported at this year's American Heart Association meeting favor devices over therapeutics in treating certain cardiovascular conditions. The PRESTO trial results were the equivalent of a dodged bullet for stent companies; it showed no benefit from the drug Tranilast, a result which leaves intact the supposition that drug-eluting stents are the best restenosis treatment. And another major trial found that implantable LVADs have superior results in treatment patients with chronic end-stage heart failure.

That low rumbling sound coming from Southern California in mid-November wasn't an earthquake—just the opposite. It was a collective sigh of relief from coronary stent manufacturers as results from the PRESTO trial, assessing the efficacy of the drug Tranilastas a potential cure for restenosis, proved disappointing.

For the past several years, a series of small studies out of Japan had suggested that Tranilasthad been successful in...

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