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Branded Life After Lipitor: Pharma Targets Unmet Needs In Dyslipidemia

Statins represent a high standard of care for managing high blood cholesterol, bolstered by a strong evidence base, but new targets like PCSK9 and CETP are nevertheless stealing the spotlight nowadays. Whether new drugs, if they make it to market, will be used beyond narrow, targeted population segments is uncertain and will depend on results from large-scale outcomes studies showing significant efficacy and, importantly, reassurance of a solid safety profile.

Emblematic of an era, Pfizer Inc.’s enormously successful statin Lipitor (atorvastatin) now has a seat on the train to the ghost town of bygone blockbusters.

Though it was late of its kind to gain FDA-approval, Lipitor became a best seller, reaching sales of $5.3 billion in the US and $10.7 billion globally in 2010. It set a spectacular clinical and commercial standard for cardiovascular therapies – and blockbusters in general – for a decade

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Final Chance To Have Your Say: Take Our Reader Survey This Week

 
• By Eleanor Malone

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Early Development Deals: Ipsen's Strategy For Biomarker-Driven Success

 
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Shape Our Content: Take The Reader Survey

 
• By Eleanor Malone

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In Partnership with Cerba Research

Prioritizing Safety in CAR-T Therapy: Patient Monitoring with Cerba Research’s Testing Portfolio

The cell and gene therapy (CGT) clinical trial landscape in general and CAR-T cell clinical trials in particular are a special focus for the FDA, EMA, and other regulatory agencies. The whole industry is thus aware of the recent FDA safety investigation and requirements for labeling CAR therapy products.

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Protagonist’s Patel: Building A Differentiated Peptide Platform With Strategic Patience

 
• By David Wild

After revolutionizing the peptide therapeutic landscape, CEO Dinesh Patel reflects on the journey from surviving the 2008 financial crisis to developing a platform now poised to deliver back-to-back blockbuster approvals.

With 75 Pipeline Candidates, TIL Therapies Gain Momentum in Solid Tumor Space

 
• By David Wild

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NewAmsterdam’s Davidson On Reviving “Failed” Drug Class To Fill Cardiovascular Treatment Gap

 
• By David Wild

After a string of high-profile failures by big pharma, Michael Davidson is positioning his company's CETP inhibitor as the next breakthrough in cardiovascular medicine. The body of data to support this position is growing.