1. In Vivo

Too Early For Tools?

Advances in high-throughput screening and metagenomic data analysis have already helped uncover the microbiome’s potential as a source of new therapeutic approaches. But more new tools will be needed to further decipher it.

AvidBiotics Corp.’s Avidocin proteins are engineered to target a single bacterium strain without collateral damage. The proteins – tweaked versions of R-type bacteriocins, or naturally occurring defensive bacterial proteins – zero in in unique surface molecules of the bacterial targets, without hitting or harming off-target bacteria. This “sniper rifle” approa

ch is potentially a very useful microbiome research tool. But the company has struggled to monetize it. That’s in part...

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