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Cyclacel's Mechanistic Approach to R&D

 
• By Chris Morrison

Cyclacel does not have a late-stage or marketed product. But a singular focus on the biology of the cell cycle, a strong early-stage pipeline and a set of broadly applicable biomarker technologies that may minimize development risk has kept investors interested. Cyclacel has been able to complement its internal pipeline with two recent in-licensing deals, and as capital cautiously returns to European biotech, the company expects to leverage its approach to build value not only in cancer but in other proliferative diseases as well.

Cyclacel Pharmaceuticals Inc. has always been a product play. Since its foundation in 1996 the Scottish biotech has focused on R&D of cell-cycle modulating compounds, building on the pioneering discoveries of CSO and founder David Lane, PhD. And in this single-mindedness is Cyclacel's staying power. "We weren't the most interesting game in town in 2000" when the genomics revolution attracted most VC funding to platforms, "but that's the way it works," says Cyclacel CEO Spiro Rombotis.

Indeed, even during the sobering genomic aftermath, when investor interest switched to late-stage products, Cyclacel didn't jump on that bandwagon...

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Turning Defense Into Attack: Snapshots Of A Changing Medtech Market And How To Respond

 
• By Ashley Yeo

Against a backdrop of shifting trade policies, the end of multilateral market approaches and renewed focus on supply chain resilience, medtechs are doubling down on innovation in products and processes – using AI – and keeping unmet needs and outcomes in the center of the target.

UK Bets On Regulatory Innovation As Competitive Advantage In Synthetic Biology

 
• By David Wild

The UK government has prioritized synthetic biology and created a "concierge service" for biotechs just as the US cuts science funding.

Chinese Firms Build Obesity Clinical Pipeline But Face Wider Hurdles

 
• By Xu Hu

Despite the ability to initiate clinical trials quickly and having strong manufacturing capacity, Chinese companies are facing multiple challenges in the obesity space.

Unpacking The Impact Of Trump’s Tariffs On Drug Pricing And Production

 
• By Ed Silverman

Big pharma plans to invest billions of dollars in US manufacturing to avoid tariffs proposed by the Trump Administration. However, the implementation of these plans may be delayed due to regulatory complexities and rising costs from tariffs, potentially impacting drug prices for consumers.

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EU Medtech Outlook: The View From MedTech Europe Experts

 
• By Ashley Yeo

MedTech Forum 2025 was less MDR-focused than in previous years, as macro issues and exogenous threats were forced further into the center of medtech business thinking.

‘Confident In Lorundrostat’s Promise’: Mineralys CEO Talks Trials And Next Steps

 
• By Sushmita Panda

In a conversation with In Vivo, CEO Jon Congleton discusses Mineralys’s data-rich journey toward an NDA filing, the significance of recent trial wins and how its candidate may offer a dual benefit in blood pressure and renal protection.

BioBytes: Qubit Pharmaceuticals Unveils Quantum AI Model For Drug Discovery

 
• By David Wild

Qubit Pharmaceuticals and Sorbonne University launched a quantum AI model that could slash drug synthesis requirements and enable exploration of previously undruggable targets.