‘We’re On The Edge Of Knowledge,’ Says Dewpoint CEO

Dewpoint Therapeutics, with headquarters in Cambridge, Massachusetts and Dresden, Germany, believes understanding and targeting biomolecular condensates – droplets without membranes that form in the cell through a process called phase separation – represents the next “tectonic shift” in drug discovery. With 16 years at investment firm Polaris Partners and multiple start-up CEO roles under his belt, CEO Amir Nashat, who received an Sc.D from Massachusetts Institute of Technology (MIT) in chemical engineering and a biology minor under the tutelage of MIT’s Bob Langer, said he’s never seen anything “so architecturally relevant … to everything in biology.”

The condensate space, said Nashat, “is probably more fundamental to a better understanding of how cells function, and how cell biology works, than anything I’ve ever seen before.” He has seen a lot: as examples, Nashat cited the introduction of population genetics with companies like deCode, or the use of gene editing with Alnylam Pharmaceuticals Inc.