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Mironid On Reducing The Burden Of Polycystic Kidney Disease

ADPKD Is The Most Common Genetic Kidney Disease

 
• By Chloe Kent

Scottish biotech Mironid is in the preclinical stages of developing a treatment for autosomal dominant polycystic kidney disease, a genetic condition which for around half of patients can led to kidney failure by the time they reach 60 years of age. In Vivo spoke to chief medical officer Cass Kelleher about the company’s development strategy.

Doctor holding a plastic model of a polycystic kidney
Around half of ADPKD patients will be in kidney failure by the time they are 60 • Source: Shutterstock

For patients with autosomal dominant polycystic kidney disease (ADKPD), abnormalities in two different genes – PKD1, which accounts for around 78% of cases, and PKD2, which accounts for around 15% – disrupt the regular development of the kidneys and cause cysts to grow, due to abnormally elevated levels of cyclic adenosine monophosphate (cAMP) enzymes.

A person has a 50% chance of developing the condition if one of their parents has one of the faulty genes, making it the most common inherited kidney disease

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