EuroPCR 2018: Several Studies Add Insight To Best Approach To Stable Coronary Disease, Utility Of FFR

24 May 2018

New clinical data presented at the EuroPCR conference in Paris, including new data from ORBITA, suggest that fractional flow reserve/ instant wave-free ratio-guided percutaneous coronary intervention may produce better long-term outcomes than PCI guided by angiography in terms of mortality, restenosis and stent thrombosis.

MT1805_Eiffel Tower_710380270 _1200 — EuroPCR 2018 is held in Paris, May 22-25 • Source: Shutterstock

New data from ORBITA, the first sham-controlled trial of percutaneous coronary intervention with drug-eluting stents in patients with stable angina, suggest that invasive physiological testing with fractional flow reserve (FFR) or instantaneous wave-free ratio (iFR) predict the impact of PCI on the patient's ischemia as seen by dobutamine stress-echocardiography, but this effect is not seen in symptom scores or exercise-time test. Results from the substudy of 196 patients also showed that PCI relieves angina in about one in every five patients treated, significantly better than placebo.

Primary investigator Rasha Al-Lamee of Imperial College in London presented invasive physiology (iFR and FFR) data from 196 ORBITA patients...