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Arena moves PAH drug forward despite Phase Ib adverse event

 
• By Mandy Jackson

Arena Pharmaceuticals is moving ahead with a Phase II clinical trial for its pulmonary arterial hypertension (PAH) drug APD811 based on data from two Phase I trials, including an incidence of transient atrial fibrillation that may have been caused by the company's oral prostacyclin (IP) receptor agonist.

Arena Pharmaceuticals is moving ahead with a Phase II clinical trial for its pulmonary arterial hypertension (PAH) drug APD811 based on data from two Phase I trials, including an incidence of transient atrial fibrillation that may have been caused by the company's oral prostacyclin (IP) receptor agonist.

San Diego-based Arena tested single ascending doses of APD811 in a Phase Ia study and evaluated the safety, tolerability and pharmacokinetics of multiple ascending doses of the drug in a placebo-controlled Phase Ib study

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