Merck Serono ditches another multiple sclerosis candidate

Merck Serono's future prospects in the multiple sclerosis market look even less impressive following its decision to drop a Phase II multiple sclerosis candidate that it licensed from Japanese firm Ono Pharmaceutical in 2011 for around €14m up front. The German company said ONO-4641/ceralifimod did not meet its threshold for continued investment, and that the termination decision was a mutual agreement.

Merck Serono's future prospects in the multiple sclerosis market look even less impressive following its decision to drop a Phase II multiple sclerosis candidate that it licensed from Japanese firm Ono Pharmaceutical in 2011 for around €14m up front. The German company said ONO-4641/ceralifimod did not meet its threshold for continued investment, and that the termination decision was a mutual agreement.

The decision leaves Merck's MS franchise, represented by its top-selling drug Rebif (the injectable interferon beta-1a), looking increasingly vulnerable in...

Read the full article – start your free trial today!

Join thousands of industry professionals who rely on Scrip for daily insights

  • Start your 7-day free trial
  • Explore trusted news, analysis, and insights
  • Access comprehensive global coverage
  • Enjoy instant access – no credit card required

More from Neurological

Prilenia, Ferrer Map Out Plans For Pridopidine In Huntington’s

 

The companies announced the publication of Phase III data that they said provide rationale for moving forward in a confirmatory trial.

AC Immune Cuts Workforce As Key Parkinson’s Readout Nears

 

The Swiss neuroscience specialist has extended its cash runway into late 2027, but will still need positive readouts in the coming months, including for its wholly owned Parkinson’s candidate.

AL-S Pharma’s AP-101 Shows Efficacy In ALS Clinical Trial

 

The Phase II study tested AP-101 safety and tolerability as the primary endpoint but showed “clinically meaningful” efficacy in exploratory endpoints.

Eisai Pulls Another Leqembi Growth Lever With First Subcutaneous Approval

 
• By 

The US FDA approved a subcutaneous version of the Biogen-partnered anti-amyloid antibody, Leqembi IQLIK, for once-weekly maintenance dosing after 18 months of I.V. treatment every two weeks.

More from Therapy Areas

AL-S Pharma’s AP-101 Shows Efficacy In ALS Clinical Trial

 

The Phase II study tested AP-101 safety and tolerability as the primary endpoint but showed “clinically meaningful” efficacy in exploratory endpoints.

Xoma On Its Royalty Model And Cleaning Up ‘Zombie’ Companies

 

Seizing an opportunity to buy out struggling 'zombie' biotechs, Xoma is helping to return investor cash and pick up potential bargain assets for itself. Its CEO and chief investment officer explained their approach to Scrip.

Sanofi Shares Slide Despite Amlitelimab Eczema Win

 
• By 

The OX40 ligand-targeting drug’s efficacy is seen as light compared with existing therapies.