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Genentech stops Erivedge IPF study before it starts

 
• By Mandy Jackson

Genentech suspended patient recruitment for a Phase II clinical trial testing the hedgehog pathway inhibitor Erivedge (vismodegib) in the treatment of idiopathic pulmonary fibrosis (IPF) before the trial began enrolling patients.

Genentech suspended patient recruitment for a Phase II clinical trial testing the hedgehog pathway inhibitor Erivedge (vismodegib) in the treatment of idiopathic pulmonary fibrosis (IPF) before the trial began enrolling patients.

The Roche company, which licensed the basal cell carcinoma drug from Curis under a broad hedgehog inhibitor deal in 2003, decided to refine the placebo-controlled Phase II study's protocol before...

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• By Andrew McConaghie

The company highlighted the KLK2-targeting agent’s safety at ASCO but it may have to rely on combinations to make pasritamig competitive.

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The drugmaker presented oral abstracts at the meeting for Libtayo in adjuvant cutaneous squamous-cell carcinoma and linvoseltamab in multiple myeloma.

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More from Therapy Areas

ASCO: Lupin Presents Early Data On PRMT5 Inhibitor

 
• By Vibha Ravi

ASCO sees the debut of Lupin’s PRMT5 inhibitor candidate LRNP7457, currently in Phase I studies in India. While no drug with this mechanism of action has been approved anywhere so far, several candidates are in clinical trials.

Bristol Will Pay BioNTech $1.5bn Up Front To Enter PD-L1xVEGF Space

 
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BMS is guaranteeing BioNTech at least $3.5bn to share development costs and potential profits on the Phase III bispecific, to compete with Summit, Merck and Pfizer.

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• By Mary Jo Laffler

Data presented at ASCO supports use of AZ’s Imfinzi for perioperative gastric cancer and BMS’s Opdivo for adjuvant treatment of head and neck cancer.