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Positive Phase IIb data from AstraZeneca in lupus and RA but PhIII not assured

 
• By Sukaina Virji

AstraZeneca's MedImmune unit has presented positive Phase IIb data at the American College of Rheumatology (ACR) meeting this week from two products highlighted by CEO Pascal Soriot as 'ones to watch' as he fended off Pfizer's unwanted advances earlier this year (scripintelligence.com, 28 May 2014). However, their progress into Phase III is not assured as AstraZeneca is waiting on data from other trials before making a decision on how to proceed.

AstraZeneca's MedImmune unit has presented positive Phase IIb data at the American College of Rheumatology (ACR) meeting this week from two products highlighted by CEO Pascal Soriot as 'ones to watch' as he fended off Pfizer's unwanted advances earlier this year (scripintelligence.com, 28 May 2014). However, their progress into Phase III is not assured as AstraZeneca is waiting on data from other trials before making a decision on how to proceed.

Sifalimumab (MEDI-545), a monoclonal antibody targeting interferon for treatment of systemic lupus erythematosus (SLE or lupus), and mavrilimumab, a monoclonal antibody targeting GM?CSF for the treatment of rheumatoid arthritis (RA), both met the primary endpoint in the trials. Sifalimumab targets interferon-alpha subtypes

More from Dermatological

Abeona Sets $3.1m Price For Rare Skin Disorder Gene Therapy

 
• By Joseph Haas

Abeona plans to offer an outcomes-based payment model for Zevaskyn, which likely will see complementary use with Krystal’s Vyjuvek in recessive dystrophic epidermolysis bullosa patients.

Seven Up For Sanofi and Regeneron With Dupixent CSU Approval

 
• By Kevin Grogan

The IL-4/IL-13 inhibitor has been approved in the US as the first targeted therapy in over a decade for chronic itching.

Almirall Looks To Dominate Across Derma Spectrum

 
• By Kevin Grogan

CEO Carlos Gallardo tells Scrip the Barcelona-based group has laid the foundations to advance four promising assets that have considerable potential for a variety of dermatological diseases.

Incyte’s Povorcitinib Looks Approvable In HS, But How Competitive?

 
• By Joseph Haas

Incyte’s JAK1 inhibitor meets the primary endpoint in two Phase III hidradenitis suppurativa trials, but the drug may not be able to supplant established biologic therapies.

More from Therapy Areas

Shionogi In $1bn Deal For Japan Tobacco’s Pharma Ops

 
• By Ian Haydock

Mid-sized Japanese pharma firm to acquire tobacco giant’s pharma operations and take private the listed Torii Pharmaceutical business, in bid to build sales reach and strengthen manufacturing.

Copycats Compound Novo’s Wegovy Growth Problems

 
• By Andrew McConaghie

The US FDA has ordered compounders of the Danish firm's obesity drug semaglutide to shut up shop later this month, but competition from Eli Lilly is only increasing.

First Win For AstraZeneca’s Enhertu In Early-Stage Breast Cancer Treatment

 
• By Andrew McConaghie

Already dominating in later lines of breast cancer treatment, Enhertu could now displace both chemotherapy combinations and Roche’s Kadcyla in early-stage HER2-positive patients.