Dynogen Pharmaceuticals Inc. is focusing on the neurological underpinnings of large, undermet GU and GI disorders including overactive bladder and irritable bowel syndrome. It is in-licensing clinical-stage compounds originally earmarked for CNS indications and developing them instead to modulate neurological targets involved in GU and GI function.
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CEO Paul Stoffels said gaining US clearance for an IND for its novel CAR-T product was demanding, but now opens up a pathway towards a pivotal study starting in 2025.
A final rejection of Leqembi could also spell the same fate for Lilly’s rival drug but public outcry and demand for Alzheimer’s therapies might force the regulator’s hand
Deal Snapshot: Including its internal efforts with bimagrumab, Lilly has been seeking a muscle-sparing therapy to complement GLP-1 obesity drugs, such as Zepbound.
Plus deals involving BioAge/JiKang, Sanyou/Medicovestor, AriBio/Acino, Intragrand/Transpire, Kaken/Twocells, Sumitomo/Novo Nordisk, NIBEC/Undisclosed, Formosa/Adalvo, Drug Farm/Amoytop, Lupin/SteinCares and Lupin/Honeywell.
The oral BTK inhibitor impresses in a Phase II trial for IgG4-related disease.
