While there, he found that when human bone marrow cells were treated in a unique way and implanted into an animal brain, the treated cells migrated throughout the brain and differentiated into human neurons. He also found that when these treated cells were implanted into a rodent eye with a damaged retina, the cells migrated to the area of damage and differentiated into new photoreceptor cells. Another discovery by Sugaya identified a small molecule that significantly increased the number of stem cells in the hippocampus and cortex of aged rats.
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CEO Paul Stoffels said gaining US clearance for an IND for its novel CAR-T product was demanding, but now opens up a pathway towards a pivotal study starting in 2025.
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