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Genentech and Inotek Pair Up in PARP Inhibition

 
• By Mark Ratner

For the first time, oncology drug development is being grounded in the ability to take advantage of a readily identifiable genetic flaw in certain types of tumor cells. Research reveals that tumor cells containing the BRCA1 or BRCA2 gene variants are exquisitely sensitive to attack by inhibitors of poly (ADP-ribose) polymerase, or PARP. Now comes a deal between PARP specialist Inotek Pharmaceuticals and Genentech.

For the first time, oncology drug development is being grounded in the ability to take advantage of a readily identifiable genetic flaw in certain types of tumor cells.

In 2005, Nature published a set of papers showing that tumor cells containing the BRCA1 or BRCA2 gene variants were exquisitely sensitive to attack by inhibitors of poly (ADP-ribose) polymerase, or PARP

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