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Sage Drug Could Help Take Stigma Out Of Postpartum Depression

 
• By Mandy Jackson

SAGE Therapeutics Inc. could offer the one in eight new mothers suffering from postpartum depression (PPD) freedom from the overwhelming condition with the first-ever drug to specifically treat PPD if the rapid and durable response to SAGE-547 in a small Phase II clinical trial holds up in future studies.

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SAGE Therapeutics Inc. could offer the one in eight new mothers suffering from postpartum depression (PPD) freedom from the overwhelming condition with the first-ever drug to specifically treat PPD if the rapid and durable response to SAGE-547 in a small Phase II clinical trial holds up in future studies.

"I'm incredibly optimistic," said University of North Carolina (UNC) associate professor Samantha Meltzer-Brody, who runs the first specialized hospital unit in the US for the treatment of PPD – a perfect partner for a company with the only drug in clinical development for the condition. SAGE-547 is in Phase III for super-refractory status epilepticus (SRSE) with data expected before the end of 2016. But given the 70% remission rate seen in women with severe PPD and the high unmet need, Sage may pursue an expedited path to approval for the maternal condition

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