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TauRx’s Data Massage Can't Work Out The Kinks Of Failed LMTX Study

 
• By Maha Elsayed

While the company is hyping the benefit seen in a subgroup analysis of the first Phase III trial of the tau aggregation inhibitor, which failed to show an overall benefit in mild-to-moderate Alzheimer's disease, Datamonitor Healthcare analyst Maha Elsayed raises some questions.

Jigsaw brain

TauRx Pharmaceuticals Ltd. is going to talk to regulators about a route forward for its Alzheimer's disease therapy LMTX, having identified positive results in a subgroup analysis of a pivotal trial that failed overall, but the analysis has limitations and there are questions that could affect the entire field of tau-based interventions in Alzheimer's disease.

TauRx Therapeutics presented the results of the first Phase III study evaluating LMTX’s (leuco-methylthioninium) efficacy and safety in Alzheimer’s disease at the Alzheimer’s Association International Conference in Toronto on July 27. The study failed to demonstrate LMTX’s therapeutic benefits in patients with mild to moderate disease

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