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Surprise! It’s A Phase III Failure

 
• By Jessica Merrill

When Phase III clinical trial failures happen it is a painful blow – to the drug manufacturer, to investors and to patients. Scrip takes a look at some of the biggest Phase III surprises since 2010.

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When Bristol-Myers Squibb Co. announced Aug. 5 that a key Phase III trial testing the checkpoint inhibitor Opdivo (nivolumab) in first-line lung cancer, CheckMate 026, missed the primary progression-free survival endpoint, the news hit the company like a ton of bricks.

Given Bristol’s leading position in cancer immunotherapy, its massive R&D investment and meticulous development of Opdivo and fellow checkpoint inhibitor...

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