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Gilead's Late-Stage R&D Misfire Gives Respite To Competing Myelofibrosis Therapies

 
• By John Davis

The JAK inhibitor momelotinib meets some endpoints but misses others in two late-stage clinical studies in myelofibrosis, a condition that has proved recalcitrant to various new approaches, leaving Incyte/Novartis’s marketed product ruxolitinib as one of the few successes.

The mixed top-line results from two Phase III studies of Gilead Sciences Inc.’s Janus kinase (JAK) 1/2 inhibitor, momelotinib, in myelofibrosis lifts the prospects of competitors marketing products for this difficult-to-treat disease.

The results also cast yet another shadow over Gilead’s strategy to diversify its product portfolio away from HIV and hepatitis C therapies, that has been hit by several late-stage failures. Earlier this month, the US company said it would discontinue development of the LOXL2 inhibitor, simtuzumab, in non-alcoholic steatohepatitis (NASH) and all other indications, and discontinued development of the MM9 inhibitor GS-5745 in ulcerative colitis and Crohn’s disease

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