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Cellectis Files IND For Talen-Edited 'Off-The-Shelf' CAR-T Candidate

Cellectis has filed an IND for US testing of its TALEN-edited CAR-T immune-oncology therapy UCART123. Servier has already begun clinical testing with Cellectis' lead program, UCART19, in Europe. The product is licensed to Pfizer in the US.

Cellectis SA of France hopes to begin clinical testing in the first half of this year with its gene edited product candidate in patients with acute myeloid leukemia (AML) and blastic plasmacytoid dendritic cell neoplasm (BPDCN). This is the first IND filing for a gene edited allogeneic product candidate in the US.

UCART (Universal Chimeric Antigen Receptor T-cells) are 'off-the-shelf' allogeneic products, which means their production can be industrialized and standardized with...

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