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AstraZeneca/Chi-Med Set For 'Selective' Pivotal Renal Cell Cancer Trial

 
• By Sukaina Virji

Chi-Med is on course to successfully hit the first of a series of value inflection points slated for 2017. Savolitinib, an inhibitor of c-Met receptor tyrosine kinase partnered with AstraZeneca, has shown early clinical benefit in multiple cancers including a large subset of renal cell carcinoma, and a pivotal Phase III trial is now being planned.

Human kidneys
• Source: Shutterstock

"We are delighted to report this highly encouraging progression-free survival data in Met-driven papillary renal cell carcinoma (PRCC), a disease with no approved treatment options," said Christian Hogg, CEO of Hutchison China MediTech Ltd. (Chi-Med). "With development of the companion diagnostic assay to screen Met-driven disease now also complete we are preparing for the initiation of our global Phase III study, the first global registration trial for savolitinib."

The positive Phase II data of savolitinib in PRCC and other savolitinib data are to be presented later this week...

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