Ardelyx's Tenapanor Data Challenge Phosphate Binders In Hyperphosphatemia

Although rate of diarrhea was higher for first-in-class tenapanor compared to phosphate binders in the first pivotal trial, drop-out rate is what counts and that was lower, say analysts, happy with the overall dataset.

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The emerging data package for Ardelyx Inc.'s first-in-class NH3E inhibitor tenapanor looks competitive with phosphate binders for treating hyperphosphatemia and bodes well for a new Phase III study coming up, analysts say.

Ardelyx is positioning tenapanor for hyperphosphatemia, or high levels of serum phosphorus, associated with end-stage renal disease (ESRD), among other indications

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