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Vertex Looks To Triple Combos For CF After Doublet Success

 
• By John Davis

Top-line results from two Phase III studies indicate Vertex’s potential new combination cystic fibrosis therapy, tezacaftor plus ivacaftor, is effective and well tolerated in certain cystic fibrosis patients, and could become the backbone of a triple combination therapy for a wider patient group.

Cystic fibrosis word cloud

Vertex Pharmaceuticals Inc. announced positive top-line results from two Phase III studies, EVOLVE and EXPAND, of its investigational cystic fibrosis therapy, tezacaftor (VX-661)/ivacaftor in the evening of March 28, in two patient subgroups, and suggested the double combination could become an important base therapy in the company’s efforts to develop a triple combination that is clinically beneficial in a higher proportion of CF patients.

“Our long-term goal is to make combination therapies available to fundamentally alter the progression of cystic fibrosis in all patients with the disease. These data are another important step on that journey,” said Vertex chairman and CEO Jeff Leiden during an analyst’s briefing held early on March 29

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