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Corbus Cystic Fibrosis Data May Justify Longer, Larger Study

 
• By Mandy Jackson

Safety was the primary endpoint in a Phase II study for the inflammation-targeting drug anabasum, but Corbus believes an efficacy signal viewed outside of the secondary endpoints justifies further development.

Cystic fibrosis word cloud

Corbus Pharmaceuticals Holdings Inc. searched for efficacy in a Phase II cystic fibrosis study for its only clinical drug candidate, anabasum (JBT-101; resunab), but the signal highlighted by the company was found in a data point outside of the trial's pre-defined endpoints.

The clinical trial's primary endpoint sought acceptable safety and tolerability for the endocannabinoid-mimetic drug, which preferentially binds to the cannabinoid-2 (CB2) receptor on activated immune cells and fibroblasts; it resolves inflammation without suppressing the immune system, which can be dangerous for CF patients as they battle severe lung infections

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