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Shire Discontinues Development Of Once-Weekly SHP656 For Hemophilia A

 
• By Mandy Jackson

Shire's cash-strapped partner Xenetic, whose technology enabled the long-acting Factor VIII, said on May 22 that SHP656 could not achieve once-weekly dosing in a Phase I/II clinical trial. The market for such a product may be limited anyway given current competition and payer preferences.

3-D Rendering Red Blood Cells

Xenetic Biosciences Inc. revealed on May 22 that its partner Shire PLC ended development of SHP656 for hemophilia A, because the long-acting coagulation Factor VIII could not be dosed once-weekly, which eliminates the product candidate's best chance for differentiation in the marketplace.

Physicians, patients and especially payers are looking for hemophilia therapies that can be dosed once-weekly or less frequently to reduce...

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