Was PD-L1 Test To Blame For Failure Of Bristol's Opdivo In '026 Trial?

NEJM editorial suggests that differences in PD-L1 testing may explain why Bristol's Opdivo failed in first-line lung cancer trial whereas Merck's Keytruda succeeded, but some analysts aren't so sure.

Malignant effusion: Pleural fluid cytology of lung (pulmonary) adenocarcinoma, a type of non small cell carcinoma.

The type of PD-L1 test and the way it was used by Bristol-Myers Squibb Co. could explain the failure of Opdivo in the CheckMate 026 first-line lung cancer trial, according to an editorial accompanying the study publication in the New England Journal of Medicine,and the author advises the assay used by competitor Merck & Co. Inc. is the best choice for newly diagnosed patients.

Full results for the CheckMate 026 study were published by David Carbone, Ohio State University Comprehensive Cancer Center, and colleagues...

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