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REVEAL: Limited Benefit Leaves Merck & Co Still Undecided On Anacetrapib's Future

 
• By Alexandra Shimmings

The commercial future of Merck & Co's CETP inhibitor anacetrapib is still in limbo as the 9% reduction in the risk of CV events seen in REVEAL underwhelms. Filings look unlikely.

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Merck & Co. Inc. is still deciding whether to file anacetrapib after the presentation of full data from the four-year, 30,000-patient REVEAL study at the European Society of Cardiology meeting in Barcelona on Aug. 29 showed it reduced the risk of major coronary events in high risk patients by a modest 9% compared with placebo, when used on top of intensive statin therapy.

The company's position remains unchanged from the one it gave in June when the positive top-line data for the investigational CETP inhibitor were announced: Merck still says it is reviewing the results with external experts and will "consider

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