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Poziotinib Shows Promise In EGFR Exon 20 Mutant NSCLC

 
• By Jung Won Shin

Hanmi and Spectrum's novel oral pan-HER inhibitor poziotinib shows promising interim results in Phase II study in NSCLC patients with EGFR exon 20 insertion mutations, an unmet need.

Digital illustration of Cancer cell in colour background
• Source: Shutterstock

An interim Phase II clinical study data for Hanmi and Spectrum's novel, oral pan-HER inhibitor poziotinib has shown evidence of significant antitumor activity, with an overall response rate of 73%, in non-small cell lung cancer patients with EGFR (epidermal growth factor receptor) exon 20 insertion mutations. Experts say the drug candidate could fill the unmet need in this NSCLC population, which lack particular treatments at present, if the drug undergoes expedited approval based on early phase data.

Hanmi Pharmaceutical Co. Ltd. president and CEO Se-Chang Kwon said the latest clinical trial result was a turning point...

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